Diagnosis, management and treatment of nosocomial pneumonia in ICU Serene VAP Bundle Ventilator Associated Pneumonia Ventilator Associated Pneumonia ( VAP) is a lung infection that occurs in patients who are on mechanical ventilation for more than 48 hours. A VAP bundle is a set of Monitoring Ventilator Associated Events: Slide Presentation Agency for Healthcare Research and Quality Ventilator associated pneumonia (VAP): develops 48 hours after endotracheal intubation